Association Between Human Papillomavirus and Colorectal Adenomas in Women: A Cross-Sectional Study: 2078

Introduction: Epidemiologic studies suggest that human papillomavirus (HPV) may increase the risk for colorectal neoplasm. However, the published data have been conflicting. The aim of this study is to investigate the association between high-risk HPV and colorectal adenomas in women. Methods: We performed a cross-sectional observational study on 631 women who underwent screening colonoscopies and HPV testing at Nassau University Medical Center from November 2009 to March. Among these, 80 patients were identified as high-risk HPV and 551 were HPV negative. Logistic regression model was performed to assess the association between high-risk HPV and colorectal adenomas. Results: Among the patients with high-risk HPV, the mean age was 51.9 years (standard deviation [SD] 9.3). There were 13.8% white, 35.0% African American, 45.0% Hispanic, and 6.2% other. The mean body mass index (BMI) was 29.3 (SD 6.5). The prevalence of colorectal adenomas was 16.3% in the HPV-positive group and 17.2% in the HPV-negative group. Furthermore, after adjustment for potential confounders including age, race, BMI, tobacco use, alcohol use, history of diabetes, hypertension, or dyslipidemia, no significant differences were found for the prevalence, size, number, and location of adenomas. Multivariate analysis in the Hispanic population showed no significant associations between high-risk HPV and colorectal adenomas. Conclusion: Our study suggests that there is no significant association between high-risk HPV and colorectal adenomas. It is especially true in the Hispanic population. Prospective studies with a larger sample size are warranted in the future.Table 1Table 2