Women With Previous Failed Ivf Benefit From Intrauterine Instillation Of Platelet Rich Plasma.

To record the improvement in the endometrial lining and pregnancy rates in Frozen Embryo Transfer (FET) cycles of women following intrauterine Platelet Rich Plasma (PRP) instillation. A prospective case control study was carried out during the period of August 2018 to March 2019 at our centre. Women in the age group of 25 to 45 years with a history of previous cancelled cycles due to poor endometrial lining undergoing FET were included. 101 women undergoing FET at our centre were included in the study, following their consent. Intrauterine instillation of approximately 1 ml of autologous PRP was carried out on day 5, day 12 of endometrial priming and 48 hours prior to embryo transfer. The endometrial thickness was evaluated by Transvaginal Ultrasound on the days of PRP instillation and embryo transfer. Serum BhCG levels were checked 14 days after the embryo transfer. 96 out of 101 women showed improvement in the endometrial lining. Of 101 women in the study, 29 women conceived (28.7%). Also, there were 10 biochemical pregnancies (9.9%). Of these 29 women, 14 had never conceived in the past and 15 women had previous pregnancy loses. Among the 45 women, who had never conceived in the past, 21 women had done multiple cycles earlier and of these 24% (n=5) got pregnant. Of the 29 pregnancies with PRP, one woman delivered, 6 women had miscarriages after cardiac activity and 15 are ongoing pregnancies. Thirty three women had past history of Genital TB. Of these, 24% (n=8) got pregnant. Of these, 5 had done multiple IVF cycles in the past and there were 3 women who had never conceived. Of the 8 pregnancies with a history of genital TB, 5 are ongoing pregnancies and 3 miscarried after cardiac activity. Intrauterine infusion of PRP has a potential to improve the endometrial lining and clinical pregnancy rates particularly in women with multiple failed attempts and also holds promise for women with past history of Genital TB where implantation rates are low.