Cohort Profile: King’s Health Partners Bladder Cancer Biobank (KHP BCaBB)

Event Abstract Back to Event Cohort Profile: King’s Health Partners Bladder Cancer Biobank (KHP BCaBB) Pinky Kotecha1, 2*, Charlotte L. Moss2, Kerri Beckmann2, Beth Russel2, Aida Santaolalla2, Harriet Wylie2, Fee Cahill2, Anna Haire2, Cheryl Gillett3, Rosemary Drescher2, Deborah Enting4, Muhammad S. Khan5, Debra JosephsShamim Khan, Muhammad4, Rajesh Nair5, Simon Hughes2, 4, Ramesh Thurairaja5, Sarah Rudman2, 4, Sachin Malde5, Kathryn Chatterton5, Sue Amery5, Simon Chowdhury2, 4 and Mieke Van Hemelrijck2 1 King's College London, United Kingdom 2 Department of Translational Oncology and Urology Research, Faculty of Life Sciences & Medicine, King's College London, United Kingdom 3 Comprehensive Cancer Centre, King’s College London, United Kingdom 4 Department of Medical Oncology, Guy’s and St Thomas’ NHS Foundation Trust, United Kingdom 5 Department of Urology, Guy’s and St Thomas’ NHS Foundation Trust, United Kingdom Background: Bladder cancer is the 8th most common cancer in men and the 16th most common cancer in women in the UK, with no improvement in outcomes over the last 25 years therefore highlighting the importance of studying the many unanswered, clinically relevant research questions. As not all bladder cancers are the same, it is important to have a biobank with detailed data on demographics, clinical and pathological characteristics. This tool is important in achieving optimal patient outcomes as it can be used in treatment selection and risk stratification. Methods: The KHP Bladder Cancer biobank, established in June 2017, has been recruiting donors from both the Urology and Oncology departments at Guy’s and St Thomas’ NHS Foundation Trust. Bladder cancer patients can be approached for consent at any point during their treatment pathway. This has allowed for a rich biobank as patients permit access to their clinical and pathological data as well as residual material from earlier diagnosis. Moreover, patients can be asked to donate surplus tissue including blood. Following consent, all routinely collected anonymised clinical data is taken and linked from the various hospital software systems, including the Electronic Patient Records and Cancer Information System. Results: A recent audit showed that from the start of this biobank up to December 2018, 389 out of about 937 patients (41.5%) have been consented to the KHP BCaBB. The tissue repository has collected 90 fresh frozen tumour samples from 178 surgical procedures (of which 73 were a biopsy), as not all specimens can be dissected for fresh frozen sampling without compromising the diagnosis. Both blood and urine samples have been collected for 38 patients, translating into 193 peripheral blood mononuclear cell vials; 238 plasma vials, 224 serum vials, 414 urine supernatant vials and 104 urine cell pellets. In addition, upon request, historic formalin fixed paraffin-embedded blocks are available for all historic material. Conclusion: The KHP BaCaBB has assembled a rich data and tissue repository, making it an ideal platform for bladder cancer research as it provides a comprehensive clinical profile about the nuances in bladder cancer. Keywords: Bladder cancer, Biobank, biobanking, data repository, biorepository Conference: Bladder Cancer Translational Research Meeting, London, United Kingdom, 29 Mar - 29 Mar, 2019. Presentation Type: Poster Topic: Development of personalised treatment Citation: Kotecha P, Moss CL, Beckmann K, Russel B, Santaolalla A, Wylie H, Cahill F, Haire A, Gillett C, Drescher R, Enting D, Khan MS, JosephsShamim Khan, Muhammad D, Nair R, Hughes S, Thurairaja R, Rudman S, Malde S, Chatterton K, Amery S, Chowdhury S and Van Hemelrijck M (2019). Cohort Profile: King’s Health Partners Bladder Cancer Biobank (KHP BCaBB). Front. Oncol. Conference Abstract: Bladder Cancer Translational Research Meeting. doi: 10.3389/conf.fonc.2019.01.00016 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Feb 2019; Published Online: 27 Sep 2019. * Correspondence: Miss. Pinky Kotecha, King's College London, London, United Kingdom, pinky.kotecha@kcl.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Pinky Kotecha Charlotte L Moss Kerri Beckmann Beth Russel Aida Santaolalla Harriet Wylie Fee Cahill Anna Haire Cheryl Gillett Rosemary Drescher Deborah Enting Muhammad S Khan Debra JosephsShamim Khan, Muhammad Rajesh Nair Simon Hughes Ramesh Thurairaja Sarah Rudman Sachin Malde Kathryn Chatterton Sue Amery Simon Chowdhury Mieke Van Hemelrijck Google Pinky Kotecha Charlotte L Moss Kerri Beckmann Beth Russel Aida Santaolalla Harriet Wylie Fee Cahill Anna Haire Cheryl Gillett Rosemary Drescher Deborah Enting Muhammad S Khan Debra JosephsShamim Khan, Muhammad Rajesh Nair Simon Hughes Ramesh Thurairaja Sarah Rudman Sachin Malde Kathryn Chatterton Sue Amery Simon Chowdhury Mieke Van Hemelrijck Google Scholar Pinky Kotecha Charlotte L Moss Kerri Beckmann Beth Russel Aida Santaolalla Harriet Wylie Fee Cahill Anna Haire Cheryl Gillett Rosemary Drescher Deborah Enting Muhammad S Khan Debra JosephsShamim Khan, Muhammad Rajesh Nair Simon Hughes Ramesh Thurairaja Sarah Rudman Sachin Malde Kathryn Chatterton Sue Amery Simon Chowdhury Mieke Van Hemelrijck PubMed Pinky Kotecha Charlotte L Moss Kerri Beckmann Beth Russel Aida Santaolalla Harriet Wylie Fee Cahill Anna Haire Cheryl Gillett Rosemary Drescher Deborah Enting Muhammad S Khan Debra JosephsShamim Khan, Muhammad Rajesh Nair Simon Hughes Ramesh Thurairaja Sarah Rudman Sachin Malde Kathryn Chatterton Sue Amery Simon Chowdhury Mieke Van Hemelrijck Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. 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