Polymeric nanoparticles favor the in vitro dermal accumulation of Protoporphyrin IX (PpIX) with optimal biocompatibility and cellular recovery in culture of healthy dermal fibroblasts after Photodynamic Therapy

Juliana de Oliveira Miguel,Darlan Barbosa da Silva,Gabriela Cristina Carvalho da Silva,Rodrigo José Corrêa,Nádia de Oliveira Miguel, Viviane Lione,Maria Bernadete Riemma Pierre

Journal of Photochemistry and Photobiology A: Chemistry（2020）

引用 5|浏览1

暂无评分

摘要

•PpIX- Np had greater location of the PpIX in the deeper layers of the skin.•Nanoparticles causes no fibroblast damage in the dark (good biocompatibility).•The increased CC50 of PpIX-Np means lower cellular phototoxicity to fibroblast.•Cell recovery ˜100% after PDT with PpIX-Np means potential for topical use.

查看译文

关键词

Photodynamic therapy,Protoporphyrin IX,Polymeric nanoparticles,Cytotoxicity in vitro,Phototoxicity in vitro,Culture of L929 fibroblast cells

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要