Clinical challenges of a co-secreting TSH/GH pituitary adenoma
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS(2019)
摘要
Co-secreting thyrotropin/growth hormone (GH) pituitary adenomas are rare; their clinical presentation and long-term management are challenging. There is also a paucity of long-term data. Due to the cell of origin, these can behave as aggressive tumours. We report a case of a pituitary plurihormonal pit-1-derived macroadenoma, with overt clinical hyperthyroidism and minimal GH excess symptoms. The diagnosis was confirmed by pathology showing elevated thyroid and GH axes with failure of physiological GH suppression, elevated pituitary glycoprotein hormone alpha subunit (alpha GSU) and macroadenoma on imaging. Pre-operatively the patient was rendered euthyroid with carbimazole and underwent successful transphenoidal adenomectomy (TSA) with surgical cure. Histopathology displayed an elevated Ki-67 of 5.2%, necessitating long-term follow-up.
更多查看译文
关键词
2019,Acromegaly,Adult,Angiography,Anxiety,Aspirin,Australia,BMI,Beta-blockers,Blood pressure,Bone mineral density,Carbimazole,DEXA scan,Dizziness,Echocardiogram,FT3,FT4,GH,GH suppression,Goitre,Goitre (multinodular),Haematoxylin and eosin staining,Headache,Heart rate,Heat intolerance,Histopathology,Hypertension,Hyperthyroidism,Hypogonadism,IGF1,Immunostaining,Insomnia,MRI,Male,Metoprolol,Osteopenia,Palpitations,Pituitary,Pituitary adenoma,Pituitary function,Plurihormonal pituitary adenoma,Prolactin,Resection of tumour,SHBG,September,Sex hormone binding globulin,Statins,Surgery,TRH stimulation,TSH,Tachycardia,Thyroid function,Thyroid ultrasonography,Thyrotrophic adenoma,Thyroxine (T4),Transsphenoidal surgery,Triiodothyronine (T3),Triiodothyronine (T3) suppression,Unique/unexpected symptoms or presentations of a disease,Ventricular hypertrophy,White
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要