Novel quinolone resistance determinant, qepA8, in Shigella flexneri isolated in the United States, 2016.

Hattie E Webb,Kaitlin A Tagg,Jessica C Chen,Justin Kim,Rebecca Lindsey,Louise K Francois Watkins,Beth E Karp,Yo Sugawara,Jason P Folster

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY（2019）

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摘要

Enterobacteriaceae, quinolone resistance is largely attributed to mutations in the quinolone resistance-determining regions (QRDR) of gyrA, gyrB, parC, and parE, and plasmid-italiciated quinolone resistance (PMQR) genes (e.g., qnr genes, aac(6')-Ib-cr, or qepA).….

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关键词

Shigella,antimicrobial resistance,qepA,qepA8,whole-genome sequencing,United States,ciprofloxacin,quinolones

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