Establishment Of Cumulative Assessment Groups Of Pesticides For Their Effects On The Thyroid

Federica Crivellente,Andy Hart, Antonio F. Hernandez-Jerez,Susanne Hougaard Bennekou, Ragnor Pedersen,Andrea Terron, Gerrit Wolterink,Luc Mohimont

EFSA JOURNAL(2019)

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Abstract
Cumulative assessment groups of pesticides have been established for two specific effects on the thyroid: firstly hypothyroidism, and secondly parafollicular cell (C-cell) hypertrophy, hyperplasia and neoplasia. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the thyroid, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation. (C) 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
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Key words
cumulative risk assessment,cumulative assessment groups,pesticides mixtures,hypothyroidism
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