Crystal structure, anti-Trypanosoma cruzi and cytotoxic activities of Cu(II) complexes bearing β-diketone and α-diimine ligands

Drielly A. Paixão, Barbara C.A. de Oliveira,Janaina do Couto Almeida,Luana M. Sousa,Carla D. Lopes,Zumira A. Carneiro,Daiane Y. Tezuka,Juan Carlos T. Clavijo,Javier Ellena,Lorena Polloni,Pedro H.A. Machado,Sérgio de Albuquerque,Robson J. de Oliveira Júnior,Silvana Guilardi,Wendell Guerra

Inorganica Chimica Acta（2020）

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摘要

•Three novel Cu(II) complexes containing β-diketone were prepared.•The X-ray structural analysis was performed.•A Cu(II) complex was active and selective toward cancer cell lines.•A Cu(II) complex and its ligand exhibited good activity against T. cruzi.

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关键词

Copper(II) complexes,β-Diketones,Cancer,Cytotoxic activity,Chagas disease

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