Activation of epithelial cells by the major kiwifruit allergen Act d 1 in human and mouse-derived intestinal model

Andrijana Nešić, Annemarie Stam,Milena Čavić,Jean Paul Ten Klooster,Raymond Pieters,Joost Smit,Marija Gavrović-Jankulović

Journal of Functional Foods（2019）

引用 7|浏览27

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摘要

•Act d 1 up-regulates tight junction proteins in Caco-2 monolayers.•Act d 1 up-regulates tight junction proteins in 2-Dimensional intestinal organoids.•Act d 1 induces release of proinflamatory cytokines in 2D organoids and Caco-2 cells.•Act d 1 impaired TJs network of E-cadherin, claudin-3 and ZO-1 in 2D-organoids.•2D mouse organoids are a promising model for assessment of intestinal cell response.

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关键词

Act d 1,Cysteine protease,Food allergy,Pro-inflammatory cytokines,TJ proteins

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