Applying synergy metrics to combination screening data: agreements, disagreements and pitfalls
Drug Discovery Today(2019)
摘要
•Different synergy metrics are commonly used interchangeably.•The interpretation of combination screens is highly dependent on the metric used.•Synergy scores should not be detached from the experimental error in the data.•Knowledge of the dose–response relationship is essential for synergy assessment.•Great care should be taken when assessing combination effects in large screens.
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