Benign Reactive Xanthogranuloma of the Cervix, a Rare Tumor of the Female Genital Tract in a Case Report

Xanthogranuloma is a benign disorder that is considered to be a very rare event when it happens in the female reproductive organs. It can mimic adnexal tumors clinically and radiologically. The vulva, the vagina, the cervix or the endometrium can be involved. It is a process during which the tissues are infiltrated by lipid-laden histiocytes mixed with lymphocytes, plasma cells and polymorphonuclear leucocytes. In this article, we are reporting a rare case of an adult xanthogranulomatous inflammation of the uterine cervix with a detailed clinical, pathologic, radiologic and follow up data. A 46-year-old lady presented with vaginal bleeding, dysmenorrhea and pelvic heaviness. She underwent a diagnostic dilation and curetting at a peripheral hospital due to increased endometrial thickness on ultrasound. Then, she was misdiagnosed with a diffused large B cell lymphoma (Non-Hodgkin Lymphoma) and was treated with two cycles of chemotherapy. At our department, abdominopelvic ultrasound and CT scan showed a 10 x 9.4 cm round cervical mass associated with hydronephrosis. A cervical biopsy was also taken turned back with a pseudotumoral xanthogranulomatous cervicitis. Consequently, a hysterectomy with bilateral salpingo oophorectomy was decided and performed taking into consideration the possibility of a coexistent associated malignancy of the reproductive organs. In contrast with juvenile xanthogranuloma, we could not have expected from our case of adult xanthogranuloma to regress. Finally, more studies and reported cases are needed in order to assess the adequate management and utility of radiotherapy/chemotherapy in such cases of Xanthogranulomatous inflammation of the female genital tract.