New alpha-pyrones from an endophytic fungus, Hypoxylon investiens J2
RSC Advances(2019)
摘要
Four new alpha-pyrones, hypotiens A-D (1-4), were isolated from a fungal endophyte, Hypoxylon investiens J2, harbored in the medicinal plant Blumea balsamifera. Their structures were determined through detailed HRMS and NMR spectroscopic data. Compounds 1-4 are new alpha-pyrone derivatives containing an unusual dimethyl substitution in the highly unsaturated side chain. Their plausible biosynthetic pathway was discussed. Biological assay indicated that compounds 1-4 showed no antimicrobial, quorum sensing inhibitory, and cytotoxic activities. The specific side chain in alpha-pyrone derivatives 1-4 might be responsible for the weak pharmacological activities.
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关键词
endophytic fungus
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