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Genetic Polymorphisms of TPMT and NUDT15 Genes and Thiopurine Treatment-Related Toxicity in Adult Patients with Acute Lymphoblastic Leukemia in Russia

Olga Gavrilina,Igor Yakutik,Elena Parovichnikova,Andrey Sudarikov,Bella Biderman,Vera Troitskaya,Galina Baskhaeva, Ksenia Zarubina,Ekaterina Kotova,Hunan Julhakyan,Valeriy Savchenko

Clinical Lymphoma Myeloma and Leukemia（2019）

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Abstract
6-mercaptopurine is the main component of therapy for ALL. It was found in previous studies that individual variability in 6-MP drug-related toxicity and treatment efficacy could be predicted by genetic polymorphisms in TPMT and NUDT15 genes. Promising biomarkers for predicting 6-MP-induced leukopenia is still unclear in the Russian population.
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Key words
acute lymphoblastic leukemia,toxicity,thopurine,TPMT,NUDT15,ALL
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