Should CNS IPI Change the Practice of Medical Oncologists in Treatment of Diffuse Large B Cell Lymphoma? A Single Center Experience

Central nervous system (CNS) relapse in diffuse large B cell lymphoma (DLBCL) is almost always fatal. Intrathecal chemotherapy (ITC) was usually given to prevent CNS relapse. Before the adoption of CNS international prognostic index (CNS-IPI), patients were variably selected for ITC prophylaxis depending on anatomical location of the tumour and extra-nodal sites. The expected impact of adoption of CNS-IPI on the practice is not well studied.