Impact of oxidative stress on protein production by Bordetella pertussis for vaccine production

Vanessa Zavatti,Hector Budman,Raymond L. Legge,Melih Tamer

Biochemical Engineering Journal（2019）

Cited 1|Views6

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Abstract

•Oxidative stress has a negative impact in PRN production by Bordetella pertussis.•Closed-loop oxygen control appears to exacerbate oxidative stress in bioreactors.•NADPH and ROS levels increase after imposition of stress with H2O2 in B. pertussis.•NADPH and ROS decrease with cell adaption after imposition of stress with H2O2.•Consumption of NADPH through enzymatic reactions could promote adaptation.

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Key words

5CP,AKGDH,cDCF,cDCFDA,CHVOL,DMSO,DO,Ex,Em,FAD,FCM,FHA,FIM2 and FIM3,LP,lpm,FSC,MSG,NADH,NADPH,OD,PBS,PCA,PLS,PMT,PRN,PT,rpm,ROS,sPRN,SSC

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