Gender Differences In Outcome, Use And Adaption To Non-Invasive Nocturnal Ventilation (Ninv) In Obstructive Sleep Apnea (Osa) Patients

OSAS comorbidity and benefits from NINV differ between genders. This study aimed to assess NINV adaptation and use parameters, and their correlations with anthropometric measures, comorbidity, sleep quality and mood in a cohort of OSA patients. Reporting for their annual checkup, NINV patients were included in a 12-month observational study after completing: Beck Depression Scale (BDI), Hamilton Anxiety Rating Scale (HAM-A), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Cues to CPAP Use Questionnaire (CCUQ). Data were collected on BMI, Mallampati, smoking, comorbidity and NINV [type, setting, residual AHI, average daily, annual and >4h use %]. 263 patients (194 M), mean age 63.51 years (SD±9.95), mean BMI 32.92 (SD±6.17). Females were older (p Within females, moderate negative correlations were found between PSQI and % of yearly (r=-0.349) and >4h/day (r=-0.43) NINV use. Women with OSA show discriminating comorbidities, including anxiety and depression, that appear to selectively influence sleep quality and impinge on NINV adaptation and % of use.