Negative regulators of Wnt signaling in non-small cell lung cancer: Theoretical basis and therapeutic potency

•Aberrant activation of Wnt signaling plays a substantial role in NSCLC.•Negative regulators of the Wnt pathway demonstrate significant anticancer effects by effectively targeting the abnormalities in Wnt signaling.•Negative regulators of the Wnt signaling may overcome the resistance of current treatment methods and lead to many new treatment strategies for NSCLC.