Phoenix dactylifera L. Fruits Date Fruit Ameliorate Oxidative Stress in 3-NP Intoxicated PC12 Cells

Introduction: Date palm fruits (DFs) are reported to possess antimutagenic, antiviral, antifungal, and anti-inflammatory properties. Effect of date fruits in the management of Huntington’s is yet to be studied. Methods: The protective effects of DF were measured in terms of superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and reduced glutathione (rGSH), malondialdehyde (MDA) and nitrate/nitrite (NO2/NO3) content in cells. Cellular adenosine triphosphate (ATP) content was also measured. Cytotoxicity assay revealed that DF has the ability to protected cellular viability against 3-NP intoxication. Results: DFs increased the SOD and GPx activities and rGSH content. On the other hand, DF decreased MDA and NO2/NO3 levels in 3-NP intoxicated cells. Interestingly, DF increased ATP content in pheochromocytoma (PC) cells. Conclusion: DF has the ability to encounter 3-NP intoxication induced biochemical changes and improves cellular ATP contents, hence may be an interestingly candidate for further investigations.