An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease
FRONTIERS IN IMMUNOLOGY(2019)
Abstract
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However; graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity and non-relapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a non-redundant role in the pathophysiology of GVHD. In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD.
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Key words
innate lymphoid cells,graft-vs.-host disease,NK cells,T cells,hematopoietic stem cell transplantation,ILCreg
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