Variation In Lpa And Calcific Aortic Valve Stenosis In Patients Undergoing Cardiac Surgery And Familial Risk Of Aortic Valve Microcalcification

Background and Aims: LPA variants are associated with calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants predict CAVS in patients with CAD is unknown. The objectives were: To test the association between LPAvariants and CAVS in patients undergoing heart surgery. To study the association between LPA and CAVS in patients with versus without CAD. To determine whether first-degree relatives of patients with CAVS and high lipoprotein(a) (Lp[a]) show evidence of aortic valve microcalcification.