Loss Of Adipose Triglyceride Lipase Affects Platelet Function

Background and Aims: In platelets, the presence of cytosolic lipid droplets and the role of their lipolytic machinery to degrade triglycerides are still elusive. According to genome-wide RNA-sequencing data from human platelets, the main neutral lipase adipose triglyceride lipase (ATGL) is expressed in platelets. However, its role in platelet function has never been addressed.