Reverse genetics systems as tools to overcome the genetic diversity of Lassa virus

Brett Beitzel, Christine E Hulseberg,Gustavo Palacios

Current Opinion in Virology（2019）

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摘要

•Lassa virus has a large geographic distribution in sub-Saharan Africa.•High genome sequence diversity among Lassa lineages.•Efficient reverse genetics techniques have been developed for LASV.•Reverse genetics can be used to obtain stocks of difficult-to-obtain viruses.

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