A Novel Biodegradable Hollow Nanocarrier Consisting Superparamagnetic Fe 3 O 4 -loaded poly-γ- glutamic Acid and Chitosan Oligosaccharide for Targeted Delivery of Sulforaphane from Broccoli Seed Extracts

The aim of this study was to synthesize a polymeric nanocarrier system loaded with superparamagnetic iron oxide nanoparticles (SPION) and the sulforaphane(SFN) through a cross-linking method in order to protect the SFN. According to this experiment, the drug-loading content and encapsulation efficiency were 29.97 +/- 0.08% and 0.34 +/- 0.41%, respectively. The total cumulative amount of SFN, released from the nanocarrier in vitro was 87.90% over a 72 h period. MTT assays indicated that the SPION-SFN-loaded nanocarrier exhibited a much higher in vitro antitumor efficacy than free SFN. Together, these results indicate that SPION-loaded nanocarrier exhibits good drug-loading ability and sustained-release function.