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Myeloid Phd2 Knockdown Drives Macrophage Apoptosis And Paracrine Fibroblast/Smooth Muscle Cell Collagen Secretion Leading To Atherosclerotic Plaque Fibrosis

K. Van Kuijk,T. Theelen, J. Demandt,E. Marsch,M. Gijbels,H. Jin,C. Reutelingsperger,J. Cosemans,L. Schurgers,P. Carmeliet,E. Biessen, M. Daemen,J. Sluimer

Atherosclerosis（2019）

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Abstract
Background and Aims: As macrophage hypoxia drives atherosclerotic plaque instability, we investigated macrophage expression and knockdown of oxygensensor HIF prolyl hydroxylase domain protein 2 (PHD2) in human and murine atherogenesis.
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Tumor Hypoxia
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