The Primary Motor Cortex Stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in <i>Rattus norvegicus</i>

Background: The primary motor cortex (M 1 ) stimulation (MCS) is a useful tool for attenuation of the peripheral neuropathic pain in patients with pharmacologically refractory pain.Furthermore, that neurological procedure may also cause antinociception in rodents with neuropathic pain.Cold allodynia is a frequent clinical finding in patients with neuropathic pain, then, we evaluated if an adapted model of neuropathy induced by chronic constriction injury (CCI) of the ischiadicus nervus (sciatic nerve) produces cold allodynia in an animal model of chronic pain.In addition, we also investigated the effect of the electrical stimulation of the M 1 on chronic neuropathic pain condition in laboratory animals.Methods: Male Wistar rats were used.An adapted model of peripheral mononeuropathy induced by CCI was carried out by placing a single loose ligature around the right sciatic nerve.The acetone test was used to evaluate the cold allodynia in CCI or Sham (without ligature) rats.The MCS (M 1 ) was performed at low-frequency (20 μA, 100 Hz) during *These authors equally contributed to this work.