A novel MuSK cell-based myasthenia gravis diagnostic assay.
Journal of neuroimmunology(2019)
摘要
To improve the clinical diagnosis of neural autoimmune diseases, we developed an in-house muscle-specific kinase (MuSK) antibody cell-based assay (CBA) and compared its performance with RIA, ELISA, and other CBAs. Sera from patients with myasthenia gravis (MG) and other autoimmune diseases were analyzed. We found 46 (18.3%) MuSK-CBA Ab positive cases among 251 AChR-Ab negative cases [patients] and 4 (0.6%) MuSK-CBA Ab positive cases [among] the 624 AChR-Ab positive samples. Comparing these with available clinic assays, our highly specific CBA method is more sensitive than commercial ELISA and IFA(indirect immunofluorescence assay).
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关键词
Myasthenia gravis,Muscle-specific kinase,Antibody,Cell-based assay,Enzyme-linked immunosorbent assay,Indirect immunofluorescence assay
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