A structure-activity relationship study of Forkhead Domain Inhibitors (FDI): The importance of halogen binding interactions.
Bioorganic Chemistry(2019)
摘要
•We determined the binding interactions exerted by FOXM1 inhibitors on the protein-DNA complex.•We established the essential role of halogen-bonding interactions between FDI-6 and Arg297.•We established the isosteric equivalency of halogen atoms in the FDI-scaffold.
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关键词
FOXM1,FDI-6,Direct FOXM1 inhibitors,Transcription factor
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