A structure-activity relationship study of Forkhead Domain Inhibitors (FDI): The importance of halogen binding interactions.

Seyed Amirhossein Tabatabaei Dakhili,David J Pérez,Keshav Gopal,Seyed Yasin Tabatabaei Dakhili,John R Ussher,Carlos A Velázquez-Martínez

Bioorganic Chemistry（2019）

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摘要

•We determined the binding interactions exerted by FOXM1 inhibitors on the protein-DNA complex.•We established the essential role of halogen-bonding interactions between FDI-6 and Arg297.•We established the isosteric equivalency of halogen atoms in the FDI-scaffold.

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关键词

FOXM1,FDI-6,Direct FOXM1 inhibitors,Transcription factor

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