Ldlrad2 Overexpression Predicts Poor Prognosis And Promotes Metastasis By Activating Wnt/Beta-Catenin/Emt Signaling Cascade In Gastric Cancer
AGING-US(2019)
摘要
The therapeutic strategies for advanced gastric cancer (GC) remain unsatisfying and limited. Therefore, it is still imperative to fully elucidate the mechanisms underlying GC aggressive progression. The prognostic value and biological functions of low density lipoprotein receptor class A domain containing protein 2 (LDLRAD2) in GC have never been studied yet. We found that LDLRAD2 expression was significantly upregulated in GC and closely correlated with poor prognosis in GC patients. Functionally, LDLRAD2 promoted epithelial-mesenchymal transition, migration and invasion, and metastasis of GC cells. Mechanistically, LDLRAD2 interacted with and inhibited Axin1 from binding to cytoplasmic beta-catenin, which facilitated the nuclear translocation of beta-catenin, thereby activating Wnt/beta-catenin pathway. Inhibition of beta-catenin activity markedly abolished LDLRAD2-induced migration, invasion and metastasis. Together, these results suggested that LDLRAD2 contributed to invasion and metastasis of GC through activating Wnt/beta-catenin pathway. LDLRAD2/ Wnt/beta-catenin axis may be a potential therapeutic target for GC treatment.
更多查看译文
关键词
LDLRAD2,prognosis,metastasis,beta-catenin,gastric cancer
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要