Site-Specific Conjugation to Cys-Engineered THIOMAB™ Antibodies.

Pragya Adhikari,Neelie Zacharias,Rachana Ohri,Jack Sadowsky

ANTIBODY-DRUG CONJUGATES: METHODS AND PROTOCOLS（2020）

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摘要

Antibodies bearing engineered cysteine residues (termed THIOMAB™ antibodies) enable the site-selective attachment of a drug, label or other payload for specific delivery to certain tissues (e.g., tumors). This Chapter describes detailed methods we have developed and optimized for the conjugation, purification and analysis of THIOMAB™ antibody drug conjugates (TDCs).

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关键词

ADC,Disulfide,Engineered cysteine,Maleimide,Site-specific conjugation,THIOMAB

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