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TGFβ induces stemness through non-canonical AKT-FOXO3a axis in oral squamous cell carcinoma.

Kan Li,Le Yang,Jingyuan Li,Chenyu Guan,Sien Zhang,Xiaomei Lao,Daiqiao Ouyang,Guangsen Zheng,Siyong Gao,Dikan Wang,Yujie Liang,Guiqing Liao

EBioMedicine（2019）

Cited 15|Views28
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Abstract
TGFβ induces stemness through non-canonical AKT-FOXO3a axis in OSCC. Our study provides a foundation to understand the mechanism of CSCs and a possible therapeutic target to eliminate CSCs.
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Key words
FOXO3a,TGFβ,Oral squamous cell carcinoma,Stem-cell like properties
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