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Multi-omics study in monozygotic twins confirm the contribution of de novo mutation to psoriasis.

Junqin Li,Haoxiang Lin,Ruixia Hou,Juan Shen,Xiaofang Li,Jianxiao Xing,Fusheng He,Xueli Wu,Xincheng Zhao,Liangdan Sun,Xing Fan,Xuping Niu,Yanmin Liu,Ruifeng Liu,Peng An,Tong Qu,Wenjuan Chang,Qiang Wang,Ling Zhou,Jiao Li,Ziyuan Wang,Juanjuan Jiao,Ying Wang,Gang Wang,Nannan Liang,Jiannan Liang,Yanyang Liang,Hui Hou,Yu Shi,Xiaohong Yang,Juan Li,Erle Dang,Guohua Yin,Xukui Yang,Guiping Zhang,Qiang Gao,Xiaodong Fang,Xinhua Li,Kaiming Zhang

Journal of Autoimmunity（2020）

Cited 12|Views40
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Abstract
•Multi-omics difference of psoriasis dis-concordance monozygotic twins are compared .•HLA allele which have large effects on psoriasis were observed on six of our twins .•Loss-of-function variants of C3 are found in psoriasis. .•De novo mutation is contributed to psoriasis. .
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Key words
Psoriasis,Monozygotic twins,De novo mutation,C3,Loss-of-function variants
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