Electrostatic Complementarity drives Amyloid/Nucleic Acid Co-assembly.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2020)
摘要
Proteinaceous plaques associated with neurodegenerative diseases contain many biopolymers including the polyanions glycosaminoglycans and nucleic acids. Polyanion-induced amyloid fibrillation has been implicated in disease etiology, but structural models for amyloid/nucleic acid co-assemblies remain limited. Here we constrain nucleic acid/peptide interactions with model peptides that exploit electrostatic complementarity and define a novel amyloid/nucleic acid co-assembly. The structure provides a model for nucleic acid/amyloid co-assembly as well as insight into the energetic determinants involved in templating amyloid assembly.
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关键词
Alzheimer's disease,biopolymers,nucleic acid,amyloid co-assembly,solid-state NMR spectroscopy
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