Polymyxin derivatives as broad-spectrum antibiotic agents.

Ma Su,Minghui Wang,Yuzhu Hong,Alekhya Nimmagadda,Ning Shen,Yan Shi,Ruixuan Gao,En Zhang,Chuanhai Cao,Jianfeng Cai

CHEMICAL COMMUNICATIONS（2019）

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摘要

We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.

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