CXCL13-mediated recruitment of intrahepatic CXCR5+CD8+T cells favors viral control in chronic HBV infection.

•CXCR5+CD8+T cells produce higher levels of HBV-specific IFN-γ and IL-21 than CXCR5−CD8+T cells.•CXCR5+CD8+T cells retain functional capacity in inhibiting HBV replication and supporting B cell antibody production.•PD1 blockade and exogenous IL-21 enhance production of IFN-γ from CXCR5+CD8+T cells.•High expression of intrahepatic CXCL13 facilitates CXCR5+CD8+T cell recruitment and promotes immune control of HBV.