MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma.

Yue Jiang,Ruli Gao,Chunxia Cao,Lauren Forbes,Jianping Li,Shelby Freeberg,Kristianna M Fredenburg,Jeb M Justice,Natalie L Silver,Lizi Wu,Sushama Varma,Robert West,Jonathan D Licht,Maria Zajac-Kaye,Alex Kentsis,Frederic J Kaye

Oral Oncology（2019）

引用 20|浏览60

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摘要

•We studied a new ACC PDX sample that express MYB-NFIB with a matched cell line.•We studied a MYB-NFIB mouse model and generated an ACC-like mammary tumor cell line.•We show MYB-specific inhibition in ACC tumor lines using a peptidomimic inhibitor.

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关键词

Adenoid cystic cancer,MYB gene,Peptidomimetic inhibitor,B-cell leukemia

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