Cellular and systemic analysis based on Polyunsaturated Fatty Acids protective effects against insulin- resistance condition

Introduction: ω3 Poly-unsaturated Fatty Acids (PUFA-ω3) have a protective and therapeutic role to prevent insulin – resistance (IR). In this study, the protective effect was evaluated through: 1) serum parameters related to IR (HOMA index and apelin serum levels); 2) hepatic insulin signaling pathway markers (phosphorylated protein kinase B, p-Ser473-AKT/PKB); 3) endoplasmic reticulum (ER) stress marker (phosphorylated transcription factor p-eIF2α); 4) mitochondrial dynamics marker (Mitofusin 2, Mfn2).