African swine fever virus replication events and cell nucleus: New insights and perspectives

•Early intranuclear ASFV genome replication, modification of host nuclear landscape and epigenetic signatures.•ASFV-A104R histone-like protein is needed for viral progeny production.•AFSV encodes for an E2 ubiquitin-conjugating enzyme that is required for viral replication cycle.•In vitro inhibition of the ASFV-topoisomerase II disrupts viral replication.•ASFV-QP509 L and Q706 L RNA helicases have non-redundant and essential activities.