SAT-230 OCCUPATIONAL HERBICIDE EXPOSURE AND DECLINING KIDNEY FUNCTIONS AMONG SUGARCANE FARMERS IN RURAL SRI LANKA.

Paraquat and Glyphosate were leading herbicides among Sugarcane Farmers (SF) hence occupational exposure is inevitable. These have been recently linked with the development of Chronic Kidney Disease of unknown aetiology (CKDu). Urinary KIM-1 and NGAL are good predictors of renal injury prior to detectable changes in serum creatinine and served as potential biomarkers in predicting tubulointerstitial damage. Although KIM-1 and NGAL are suggested to be useful biomarkers in determining kidney injury in rural Sri Lankan paddy farmers, no simultaneous studies have so far measured frequently used herbicides and their association with renal biomarkers.