Rapid Removal Of Myeloma Light Chains By Continuous Veno-Venous Hemofiltration In A Patient With Acute Cast Nephropathy As A Result Of Lambda Light Chain Myeloma

Myeloma cast nephropathy or myeloma kidney (MK) is a complication observed in up to one third of patients with multiple myeloma (MM). MM patients who recover kidney function have longer remissions and increased overall survival. Previous attempts at light chain reduction with the use of plasma exchange in addition to chemotherapy have not consistently improved patient outcomes and remains an area of research. The inefficiency of plasma exchange is due to the high volume of distribution of light chains in the extravascular space which will repopulate the vascular space once the exchange procedure is complete.