Mon-116 study of calcium carbonate versus sevelamer on vascular stiffness in haemodialysis patients.

Patients with chronic kidney disease (CKD) develop accelerated vascular stiffening, contributing to increased mortality and morbidity. Pulse wave velocity (PWV) provides a useful clinical measure of arterial compliance. Studies have shown that the phosphate binder (PB) sevelamer, when compared to calcium-based PB (CBPB), may be associated with attenuation of vascular stiffening and calcification. Currently, there is a paucity of data comparing the effects of sevelamer versus CBPB on PWV. We report an interim analysis of pulse wave velocity in a cross over study of phosphate binders.