Single cell exome analysis of hereditary breast and gynecologic cancer loci

S.M. Bedell,Z. Chang, Y. Zhang,L. Uppendahl, A. Grad,S. Talukdar, A. Wilhite,R. Zhang,J. Wang,S.A. Mullany,T. Starr,B. Winterhoff

Gynecologic Oncology（2019）

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摘要

Objective: To assess the technical quality and potential diagnostic utility of single-cell DNA sequencing in ovarian cancer (OVCA) for detecting subclonal heterogeneity of clinically relevant mutations.

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