18F-FDG PET Predicts Hematologic Toxicity in Locally Advanced Anal Cancer Patients Treated with Chemoradiation
Advances in Radiation Oncology(2019)
摘要
Purpose: Hematologic toxicity ( HT) during chemoradiation therapy (CRT) for anal cancer can lead to treatment breaks that compromise efficacy. We hypothesized that CRT-induced HT correlates with changes in active bone marrow (ABM) characterized by pre-/post-CRT positron emission tomography (PET)/computed tomography. Methods and materials: Data from 36 patients with anal cancer who were treated with 18-Ffluorodeoxyglucose PET/computed tomography scans 2 weeks before and 6 to 16 weeks after CRT were analyzed. Complete blood counts with differential within 2 weeks from, weekly during, and 2 week after treatment were obtained. HT was defined as baseline complete blood count change to nadir and posttreatment recovery. Total bone marrow was segmented into 2 subregions: lumbosacral (LS) pelvis (L5 vertebrae, sacrum, and coccyx) and lower pelvis (LP) (ilium, femoral head/neck, and greater and lesser trochanter). PET ABM was characterized as the volume having standard uptake value (SUV) greater than the mean uptake of unirradiated extrapelvic bone marrow. PET variables of pre-/post-CRT and HT predictors were analyzed by linear regression. Results: Average pelvic ABM was significantly reduced from 52% to 41% in pre- to post-CRT PET scans for all patients (P = .0012). Regional analysis indicated significant post-CRT reduction of LS-ABM (P < .0001) and LP-ABM (P = .006). Linear regression analysis identified post-CRT SUVmean, differential Delta SUVmean, and Delta ABM as correlating significantly with pre- and posttreatment HT. Delta WBC linearly correlated with Delta ABM of LS and LP pelvis (P = .033 and P = .028, respectively). Dosimetrically, ABM was sensitive to higher radiation doses (>50 Gy) in terms of acute hematologic Delta WBC (P = .021) and Delta ANC(P = .028). HT increased with increasing volume of ABM receiving 40 Gy. The results also suggest that ABM V40 Gy <= 20% to 25% may significantly reduce the risk of HT. Conclusions: HT was significantly associated with ABM in patients with anal cancer who were treated with CRT. LS-ABM was a robust surrogate for evaluating CRT-induced HT. Our results suggest implementation of ABM dosimetric constraints, V40 Gy <= 20-25%, may significantly reduce HT and lead to decreased treatment delays associated with clinical outcomes. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.
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关键词
FDG-PET/CT Imaging,Anal Cancer,Metastatic Anal Cancer
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