COMPARATIVE IN-VIVO INVESTIGATION OF ANTIPYRETIC ACTIVITY OF THE METHNAOLIC EXTRACT OF TWO PLANTS OF FAMILY FABACAEAE

To evaluate the in vivo antipyretic activity of a methanolic extract of Vigna unguiculata Linn. and Phaseolus vulgaris . The In-vivo antipyretic potentials became determined via brewer’s yeast and DNP induced pyrexia techniques. Antipyretic results of methanolic extract of V. unguiculata and P. vulgaris has been investigated at doses 200mg/kg b. w. and 400mg/kg b. w. for DNP precipitated pyrexia methods, Extracts of both of V. ungiculata and P. vulgaris (200 and 400 mg/kg) produced dose-structured and widespread (p<0.01, 0.001) inhibition of temperature elevation with height effect produced at the 1st hour of administration of plant extract. At this time interval, the improved temperature did no longer decrease for the standard drug, aspirin (100 mg kg−1). Significant inhibition of temperature elevation by way of the extract became determined from 1-hour of post-treatment. In case of brewer’s yeast caused pyrexia strategies, both of the methanolic crude extracts of V. unguiculata and P. vulgaris confirmed antipyretic potentials, wherein P. vulgaris showed highest antipyretic pastime between these plant samples, while the V. unguiculata Confirmed lowest antipyretic activity. This experiment gives evidence for the antipyretic hobby of methanolic extract of V. unguiculata and P. vulgaris which, which can partly make a contribution to its ethnic clinical use.