Nutritional status, IL-6 serum concentration and prediction of cardiovascular complications in haemodialised patients with end-stage chronic renal disease

There are over 21 thousand haemodialysis patients in Poland. The mortality rate is over 20%. New clinical problems are observed, such as the MIA syndrom (malnutrition, inflammation, atherosclerosis). Aim: The aim of the study was to evaluate the correlation between the nutritional status, IL-6 serum concentration and the frequency of cardiovascular complications in a group of patients with end stage renal kidney insufficiency treated by haemoclialysis. The prospective study covered 53 patients divided into two groups: malnourished (group 1) and with the correct state of nutrition (group 2). All patients were haemodialised three times a week in accordance with the established medical procedures. Laboratory tests (IL-6, CRP), and observations were carried out in three consecutive measurements, marked as I, H and HI study, covering a period of 6 months. At the same time, anthropometric parameters of the nutritional status were evaluated. Cardiological complications were analysed over a 7-month period. The results of the nutritional study obtained in group 1 were statistically significantly lower than in group 2, but the incidence of cardiovascular complications was higher. A significant correlation between the serum IL-6 concentration and the risk of cardiovascular complications (OR 1.53; p = 0.04) was observed. The probability of cardiovascular complications depending on the thickness of the triceps skin-fat fold in the entire study group was statistically significant (OR 0.34; p = 0.04). Results of the study suggest that the monitoring of selected anthropometric, biochemical measurement not only gives an opportunity to assess the nutritional status of haemodialysed patients, but may be also crucial in early diagnosis of cardiovascular complications.