Immunomodulation of the Antitumor Response Induced by Alpha Radiation-Based Brachytherapy Results in the Elimination of Spontaneous Lung Metastases in a Triple Negative Breast Cancer Mice Model and in the Cure of Colon Cancer Bearing Mice

Diffusing alpha emitters Radiation Therapy (DaRT) is a unique brachytherapy treatment, in which highly-destructive short-lived alpha-emitting atoms are dispersed to a therapeutically-significant range inside the solid tumor. It was previously shown that in situ ablation by DaRT induces a systemic antitumor immune response, evidenced by prolonged survival and reduced rates of lung metastases and of primary- or challenged- tumor development. Here, we aimed to investigate strategies to boost the systemic antitumor immune response induced by DaRT.