SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW FULLY FUSED QUINAZOLINE DERIVATIVES

Some fully fused quinazoline derivatives have been synthesized via condensation of 3-formylpyrazolo[5,1-b]quinazolin-9(1H)one 2 with bifunctional reagents followed by ring closure reactions. The structures of the products have been established by their elemental analyses and spectral data (UV, IR, H-1 NMR, mass and X-ray). The antibacterial activity of some products have been also described. Compounds 7, 12b and 13 show a relatively better activity against some tested bacteria in comparison with gentamycin.