Activité physique, obésité et cancer du sein : quelles conclusions pratiques ?

Introduction and purpose. - According to the International Agency for Research on Cancer (IARC), in the European Union, 13,000 cases of breast cancer (BC) could be annually prevented by maintaining a normal body weight. The purpose of this review is to analyze the relationships between Physical Activity (PA) and BC, the latter being a disease associated with overweight and obesity. Results. - PA is involved in the relationship linking overweight and obesity to the BC, because it can induce a fat mass loss, resulting into a host of beneficial physiological alterations. PA may modify circulating levels of sex hormones, fuel-regulating hormones, markers of systemic inflammation, adipokines and oxidative stress. Data suggest that the most significant effects are found with aerobic AP, as walking, with high volume (ie, 200-300 min/week) and moderate intensities. (C) 2019 Elsevier Masson SAS. All rights reserved.