The making and function of CAR cells
Immunology Letters（2019）
摘要
•CARs transmit modified information/signals of choice across the plasma membrane.•Unlike wildtype receptors, CARs can even invert signals into the opposite.•Now, the hunt is on for consensus signaling domains ensuring longevity of CAR cells.•Universal, off-the-shelf and broadly applicable CAR cell types would be desirable.•Diseases with nonmalignant polyclonal cellular expansions are future CAR targets.
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关键词
ADCC,APC,APRIL,BAFF,BBIR,BCMA,CAR,Cas9,CD,CID,CMV,CRISPR,CRS,CTL,CTLA-4,EAE,EGFR,ELRD,EMA,Fab,Fc,FcεRI,FDA,FKBP,GVHD,HEL,HER2,HLA,huEGFRTt,iCAR,iCasp9,ICOS,IFN,Ig,IL,IL13Rα2,IL2R,IL7R,iPSC,ITAM,LAG-3,MBP,MHC,NK cell,NKT cell,PBMCs,PD-1,PD-L1,PSCA,PSMA,RMTC,scFV,STAT3,SUPRA CAR,tanCAR,TCM cell,TCR,Th cell,TIM-3,TNP,TRAC locus,TRBC locus,Treg cell,VH,VL
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