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TRPC1 and ORAI1 channels in colon cancer

Carlos Villalobos,Miriam Hernández-Morales,Lucía G. Gutiérrez,Lucía Núñez

Cell Calcium（2019）

Cited 27|Views19
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Abstract
•Colon cancer cells show remodeling of store-operated channels (SOCs).•SOCs in normal cells contain only Orai1 channels.•SOCs in colon cancer contain Orai1 and TRPC channels.•Mitochondria help sustaining SOCs in colon cancer cells.•Polyamines contribute to SOC remodeling in colon cancer.
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Key words
Colorectal cancer,TRPC1 channels,Store-operated Ca2+ entry,Store-operated currents,Mitochondria,Polyamines
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