Light-activated chimeric GPCRs: limitations and opportunities
Current Opinion in Structural Biology（2019）
Abstract
•Optogenetics can control biological processes with high spatio-temporal precision.•Light-activated GPCRs (OptoXRs) were developed using chimeric protein engineering.•OptoXRs were used to activate GPCR signalling ex vivo and in vivo.•Open questions include the signalling specificity and bias of OptoXRs.•Next-generation OptoXRs will have optimized and broader functionality.
MoreTranslated text
Key words
Optogenetics,Neural Circuitry
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined